Molecular Formula | C12H18BNO4S |
Molar Mass | 283.15 |
Density | 1.24±0.1 g/cm3(Predicted) |
Boling Point | 427.1±47.0 °C(Predicted) |
Flash Point | 212.129°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 10.00±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.543 |
Application | Phenylsulfonamido-4-boric acid is a boric acid derivative, boric acid derivatives are widely used in organic synthesis for the formation of carbon-carbon bonds. In Suzuki coupling, aryl halides and boric acid aryl or vinyl ester or boric acid are coupled using Pd(PPh3)4. |
Uses | Phenylsulfonamido-4-boric acid is a carboxylic acid derivative, mainly used as a pharmaceutical intermediate. |
preparation | potassium acetate (2.5g, 24.4 mmol) is added to a solution of 4-bromobenzenesulfonamide (2.00g, 9.32 mmol) and bis (pinacol) diboron (2.40g, 9.32 mmol) in DMSO(20 ml) and degas the mixture for 45 minutes. Then [1,1 '-bis (diphenylphosphino) ferrocene] dichloropalladium (II)(220 mg, 0.26 mmol) was added and the mixture was heated to 90°C for 16 hours. Once cooled, the reaction mixture was diluted with EtOAc(30 ml), washed with water (3 × 30 ml), dried with MgSO4 and concentrated under vacuum. The residue was ground from Et2O(50 ml) and HCl(1M,50 ml), the resulting solid was dissolved in CH2Cl2(30 ml) and filtered through a silicone pad cleaned with Et2O, and then concentrated to obtain phenylsulfonamido-4-boric acid as an off-white solid, with a 13% yield of 550 mg. |